IV Induction Agents

2010b(6)03b(4) Describe how computer controlled infusion devices target and maintain constant blood concentrations of propofol

2009b(2)01a(13)98a(10) What are the potential side effects of propofol and its formulations

2008b(2) Describe the pharmacokinetic principles of TIVA using propofol

2006a(4) Describe the pharmacodynamic properties of propofol and how this influences its clinical usage

2005b(4)01a(11) Define the term context-sensitive half time. How does it differ from the half life typically quoted for a drug?

2004b(7) Outline the factors which influence the elimination half-life of propofol

2003a(2)99a(13) Outline the neuropharmacology of thiopentone covering its site of action, EEG changes and effects on cerebral blood flow and ICP

2002a(11) Outline the effects of STP and ketamine not mediated via the CNS

2002a(10)99b(16)98a(13)95b(18) Outline the factors that determine recovery (offset of action) after ceasing a drug infusion

2001b(9)97a(10) What is ‘clearance’? Using propofol as an example, briefly explain its importance

1999b(14) Briefly outline the effects of IV induction agents not mediated via the CNS

1998b(9) Write short notes contrasting the CVS effects of propofol and ketamine seen clinically

1997b(9) List the properties of an ideal IV anaesthetic agent. To what extent does methohexitone conform to this?

MAKEUP Etomidate

MAKEUP Ketamine

MAKEUP Methohexitone

MAKEUP Propofol

MKEUP Thiopentone