Primary Examination SAQs

Study notes for the ANZCA Primary Examination SAQs

Pharmacodynamics & Pharmacokinetics

with 6 comments

2011a(3) Outline the effects of liver failure on drug kinetics and dynamics

2009b(4) Describe the effect of obesity on pharmacokinetics and the potential clinical implications, providing relevant examples

2008a(3) Describe the ideal pharmacokinetic and pharmacodynamic properties of agents used for sedation. Outline the pharmacology of midazolam and propofol with reference to these ideal properties

2007a(3)Discuss factors contributing to interindividual variability in therapeutic response to opioid analgesic medications

2006a(2)00b(9)What is an isomer? Briefly write an account of types of isomers and the significance to drugs in anaesthesia

2006b(3)05a(3)Describe the factors which contribute to the interindividual variability in drug response seen with IV anaesthetic induction agents

2005b(2)99b(13)95b(19)Describe with graphs ‘potency’ ‘efficacy’ ‘partial agonist”competitive antagonist’ and ‘therapeutic index’

2004b(1)01a(9)96b(12)Briefly describe how drugs may produce their pharmacological effect. Illustrate each with examples

2003a(4)Outline the potential problems associated with additives used to make medications suitable for IV injection

2002b(2)Briefly describe the factors affecting the uptake of an orally administered drug

2000a(14)Discuss roles of plasma esterases on drugs used in anaesthesia

1996a(16)Define therapeutic index and briefly outline its significance. Briefly describe also therapeutic ratio and use of CVS : CNS toxicity ratio

1996a(13)Describe briefly the factors determining transdermal uptake of drugs and give examples. Outline advantages and disadvantages

1995b(13)Give a brief account of drug protein binding and outline its significance

Advertisements

Written by primarysaqs

December 31, 2009 at 10:59 am

6 Responses

Subscribe to comments with RSS.

  1. Hi Amanda,
    Thanks again for a great site, your answer to 2006a(2)/00b(9): What is an isomer? states – 2 different types exist: structural and optical isomers.

    Most text books divide isomers into structural isomerism and stereo isomerism with other branches under these two main headings. E.g. Peck page 45.

    Cheers, Graham

    Graham Wesley

    December 9, 2010 at 2:26 pm

    • Hi Graham

      Thanks for the support for the website – I am glad that you are utilising it! I have changed the wording in the isomer question – thanks for picking up the typo!

      Good luck with the study!

      Amanda

      primarysaqs

      December 9, 2010 at 7:11 pm

  2. Hi Amanda! I’ve been using your site a lot lately, thanks, it is great! I can’t seem to find a worked out answer or good textbook reference for this question from 2009(b): ” Describe the effect of obesity on pharmacokinetics and the potential clinical implications, providing relevant examples.” I worked out a 2 page answer which I would like to compare with others and get some feedback, I am not quire sure if this is good enough but generally tried to follow the examiners feedback for a bit of help. If you are interested in this answer, or if you know where I can find this answer, please email (theodevries@doctors.org.uk) or facebook me.

    Thanks!
    Theo

    Theo de Vries

    October 18, 2011 at 3:53 pm

    • No problems

      Email me the answer and I will get back to you ASAP! Try to limit your answer to 1 page to get the most important points..

      There are some Oxford Mini Books, and the CEACCP articles on Obesity and Anaesthesia and recent BJA articles (supplement from 2010) on the subject which are very comprehensive.

      Good luck!

      primarysaqs

      October 18, 2011 at 7:41 pm

  3. Hi Amanda,

    Youve done a wonderful job with the site.
    Quick question. With regards to protiein binding in 1995b(13), when you put down ionic or electrostatic, did you mean “ionic or covalent”? I beleive that electrostatic is the type of bond and ionic or covalent are the subset of bond types.

    luke

    April 3, 2012 at 9:35 pm

    • Hi Luke

      Covalent, ionic and electrostatic (or Van de Waals) bonding are three distinct types of bonds.

      Covalent is the type of bonding keeping atoms joined together to make up molecules such as proteins. They are strong bonds that are not involved in most dynamic protein-drug interactions but can occur with irreversible interactions such as non-competitive binding of phenoxybenzamine with the alpha 1 receptor or PPI’s with the proton pump in the stomach.

      Ionic bonds involve ionised molecules, either positive or negatively charged through losing or gaining electrons respectively. These bonds are relevant to proteins as they are generally negatively charged and therefore attract and repel positive and negatively charged molecules respecitively. For example Ca2+ and H+ compete for binding sites on Albumin and can displace each other where there concentrations change.

      Electrostatic or Van de Waals bonds are the weakest type and involve electrical dipoles forming in uncharged molecules dues to an imbalance in electron attraction between atoms. A good example is water which has a particularly strong electrical dipole due to the H-O bond which is often referred to as a “hydrogen bond”. This is still a subset of electrostatic bonds. This is relevant for protein binding as the H-O bond is very prevalent (H-S to a lesser degree) on all proteins.

      AD

      primarysaqs

      April 4, 2012 at 6:24 pm


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: